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Busirone (Buspirone)
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Buspirone

Busirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, Busirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. Unlike many drugs used to treat anxiety, Busirone does not exhibit anticonvulsant, sedative, hypnotic, and muscle-relaxant properties. Due to these characteristics, Busirone been termed 'anxioselective'. First synthesized in 1968 then patented in 1975, it is commonly marketed under the brand name Busirone. Busirone was first approved in 1986 by the FDA and has been used to treat anxiety disorders, such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. It has also been used as a second-line therapy for unipolar depression when the use of selective serotonin reuptake inhibitors (SSRIs) is deemed clinically inadequate or inappropriate. The potential use of Busirone in combination with melatonin in depression and cognitive impairment via promoting neurogenesis has also been investigated.

Other names for this medication:
Buspirone, Buspar, Ansial, Ansitec, Ansiten, Anxinil, Anxiron, Bespar, Busansil, Busirone, Buspin, Buspiron, Buspirona, Ledion, Narol, Neurosine, Paxon, Sorbon, Spamilan, Spitomin,

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Stable isotope signatures of defined OM sources from the study watersheds, Shawnigan Lake (SHL) and Elk Lake (ELL), were compared with sedimentary proxy records. Most current investigations have employed limited modalities (either medication or behavioural) and few have included treatment comparisons. Here, we show in the aortas of chronically hypercholesterolemic rabbits (a model of late-stage atherosclerosis), both subunits and specific activity of the NO receptor soluble guanylyl cyclase (sGC) were significantly reduced, whereas overall NO synthase activity was unaffected. In vitro evaluation of different protocols for the induction of mesenchymal stem cells to insulin-producing cells.

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Surgical indications and limitations of transsphenoidal surgery and intentionally staged transsphenoidal surgery for large pituitary tumors were investigated by retrospective analysis of the surgical and neuroradiological findings of 22 patients with large tumor and suprasellar extension. Furthermore, using a prophase FISH ordering system, we sublocalized ZNF179 proximally to LLGL which lies on the critical region for SMS. Source identification and sedimentary record of polycyclic aromatic hydrocarbons in Lake Bled (NW Slovenia) using stable carbon isotopes. Bronchiolitis obliterans syndrome (BOS) is one of the most important factors limiting the long-term survival of lung transplant recipients (LTR), however its pathogenesis still remains unclear.

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Up-to-date computed tomographic findings on the para- and perirenal spaces under normal and pathologic conditions Class suspension is the most direct strategy to prevent the spread of disease through elementary or secondary schools by blocking the contact network. The samples were collected from a 57 year-old Hong Kong gentleman who diagnosed to have undifferentiated type of nasopharyngeal carcinoma. Pain Management 2004--Analyzing regulatory, commercial and pharmaceutical practices. The illusion of end-of-life resource savings with advance directives.

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Water soluble compounds (non-keratins) associated with the skin flakes of the human scalp. Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development. Small-bowel lymphoma and regional enteritis: radiographic similarities.

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General practice education and training in southern China: recent development and ongoing challenges under the health care reform. Efficacy of telbivudine in Taiwanese chronic hepatitis B patients compared with GLOBE extension study and predicting treatment outcome by HBV DNA kinetics at week 24. However, one nosocomial strain was consistent in having reduced susceptibility when using both guidelines without having been directly exposed to echinocandins beforehand and no mutations were found in the FKS1 gene for hot spot 1 and/or hot spot 2 regions, thereby highlighting selective pressure regarding widespread antifungal use in tertiary healthcare centres. Collagen gentamicin for prevention of sternal wound infection: effective or not?

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Procoagulant activity of purified protein derivative-stimulated pleural effusion mononuclear cells in tuberculous pleurisy. Enzyme activity stains on native gel separations of partially purified kidney homogenates was associated with two major bands of GTK (KAT-I)-activity in WKY and Wistar rats, KAT-Ia and KAT-Ib.

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Functional status, pain level, and work status were assessed at baseline and after 1 year. Determination of the amino acid compositions of the dimeric forms provided support for their content of monomeric constituents as established earlier by electrophoretic analysis. Case-control study of severe life threatening asthma (SLTA) in adults: psychological factors. Early survival is a key life-history trait that often accounts for a large part of the variation in individual fitness and shapes population dynamics. Western blot showed that the LC3-II/actin was higher in the SCI than in the control group.

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DADP/TCTNB and DADP/TBTNB prefer sliding along a diagonal direction on the a-c face and generating strong intermolecular repulsions, compared to DADP/TITNB, which slides parallel to the b-c face. Analyses of sister-chromatid exchange and cell-cycle kinetics in mouse T- and B-lymphocytes from peripheral blood cultures. Hypothetical neural mechanism that may play a role in mental rotation: an attractor neural network model. Changes in the biliary system after gastric bypass are not well defined.

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For light microscopy, 5-microm sections were cut and stained with hematoxylin-eosin. Previous studies have suggested that the abnormalities present in dogs which are developing a distal axonal neuropathy or in some dogs with idiopathic megaoesophagus may be limited to the proprioceptive elements of the oesophageal innervation. Short-term triggering of monocytes with TsSPs early during monocyte-to-macrophage differentiation imprinted these phenotypic alterations, suggesting long-lasting epigenetic changes.

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Surgical treatment and role of dynamic defecography after ileal pouch-anal anastomosis: technical solutions to a difficult problem. Rhinoconjunctivitis, asthma-like symptoms, FEV1 and AR post-Methacholine Bronchial Challenge (MBC) test results, FENO measurements and EP were all investigated in apprentice bakers, pastry-makers and hairdressers not suffering from asthma. Inhibitory augmentin injection 1.2g effect of some mucopolysaccharides on the lipolytic activity of the aorta of animals. However, the cellular localization of these changes and whether the alterations might be associated with an increase in cell number within proliferative regions, such as the dentate gyrus, were unknown. A literature review was performed using MEDLINE and key words related to experimental and clinical studies concerning shock and reperfusion.

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The caudal neurosecretory system in the teleost Janynsia lineata Influence of thermolabile pantoprazole 20 mg is an effective maintenance enterotoxin bacteria of Enterobacter genus on the immune system of mice was studied. Cyclooxygenase 2, pS2, inducible nitric oxide synthase and transforming growth factor alpha in gastric adaptation to stress.

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