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Topiramate
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Topiramate

Topiramate is an oral drug that is used to prevent the seizures of epilepsy. It is an anti-epileptic or anti-seizure drug. It is used primarily among patients who are not controlled by other anti-epileptic drugs. About 1 in 4 Americans diagnosed with epilepsy has seizures that resist treatment with other anti-epileptic drugs. Topiramate also prevents migraine headaches. Seizures are due to the abnormal activity ("firing") of nerves in the brain, and the abnormal activity spreads to smaller or larger portions of the brain. Although Topiramate's exact mechanism of action is unknown, scientific studies suggest that it may alter neurotransmitters within the brain. Neurotransmitters are chemicals that nerves manufacture and use to communicate with other nearby nerves. By altering the production or action of the neurotransmitters, Topiramate may suppress the abnormal activity of the nerves in the brain that cause the seizures or may prevent the abnormal activity from spreading to other nerves. Other studies suggest that Topiramate may suppress the nerves directly (i.e., not by altering neurotransmitters) and make them less likely to fire. The FDA approved Topiramate as a tablet in 1997. The sprinkle capsules were approved in October 1998.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Fatty acid profiles were analyzed in phospholipids isolated from maternal plasma and from umbilical plasma and cord vessel walls. Reduction in the number of reactive sulfhydryl groups from eight per dimer to four accompanies inactivation of the enzyme, but no alteration in electrophoretic mobility is detectable.

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Immunoblot data showed that GDNF caused a transient activation, whereas neurturin caused a sustained activation, of both p44/p42 MAP kinases and PLCgamma. Nocturia: Current Levels of Evidence and Recommendations From the International Consultation on Male Lower Urinary Tract Symptoms. The information contained in these focal nuclear microenvironments must be inherited during cell division to sustain physiologically responsive gene expression in progeny cells.

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Thirty renal transplant patients were prospectively screened for CMV infection after ALA treatment. To examine the internal consistency, test-retest reliability, construct validity, discriminant validity and responsiveness of the Ghent Participation Scale. Acute Embolic Cerebral Infarction and Coronary Artery Embolism in a Patient with Atrial Fibrillation Caused by Similar Thrombi. Prevention of negative symptom psychopathologies in first-episode schizophrenia: two-year effects of reducing the duration of untreated psychosis.

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Bacillus (B.) anthracis is the pathogen that causes fatal anthrax. Cerebellar lesions have classically been considered not to cause epilepsy. Primary human neutrophils were isolated from peripheral blood of healthy volunteers and cultured in vitro with dexamethasone.

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Protective effect of geranylgeranylacetone against radiation-induced delayed effects on human keratinocytes. show that the bromodomain of PCAF acetylase specifically binds to acetylated Tat and leads to dissociation of Tat from TAR. By immunofluorescence we have identified ICP8 as nuclear protein. Automatic and efficient R wave discrimination in the right atrium using a two-state hidden Markov model.

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This study was designed to investigate the effects of avasimibe on human coronary atherosclerosis. To test the model, 47 geese were divided in two experiments, testing five different vaccine groups and two sham groups (challenged and unchallenged).

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Full-length FatB cDNA was cloned from buds of Lonicera japonica Thunb., Lonicera japonica Thunb. In this study, we present a systematic approach which combines colorectal cancer (CRC) cell lines, namely 1638N-T1 and CMT-93, and well-established computational methods in order to compare these cell lines on the level of transcriptional regulation as well as on a pathway level, i.e., the cancer cell-intrinsic pathway repertoire. However, in above applications, the problems of broad size distribution and poor reproducibility of particles, and deactivation of protein during the preparation, storage and release, are still big challenges.

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The transcription factor forkhead box P3 (FoxP3) has been used to identify regulatory T cells in humans and is thought to correlate with tolerance to allogeneic organ transplant. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. The authors present experimental and image reconstruction methods with which 2D SOS distributions can be accurately acquired and reconstructed, and with which the SOS map can be used subsequently to reconstruct highly accurate PA tomograms. Thus, it determines gaps and drawbacks in the prior studies which are greatly useful to design more accurate investigations in the future.

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Pattern formation in 4:1 resonance of the periodically forced CO oxidation on Pt(110). These systems are based on the design of a pusher plate actuated blood pump, driven by a small brushless dc electric motor and rollerscrew driver. Value of unilateral optic atrophy symptoms in the anterior stage of cerebral tumors

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When forskolin was employed to elevate cAMP the reduction affected by 10 microM DADLE was counteracted by preincubation of the cells with GM1. Furthermore, our data suggest that mitoxantrone may be associated with increased toxicity compared with prednisone alone. LDL apheresis has served to protect the lives of patients from life threatening diseases like myocardial infarction although observations for more than 10 years in some laboratories have shown that the progression of atherosclerosis has taken place in many patients, and more importantly, the involvement of the aortic valve with calcification has developed, especially in patients who had homozygous FH, making this the most obstinate complication of FH. Apart from snRNA and snoRNA, 560 and 619 microRNAs (miRNAs), including 5 and 2 novel miRNAs, were identified in male and female worms, respectively, without piRNAs being detected in either sex. This case series emphasizes the need for finding an optimal treatment regimen.

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Hybrids containing a single human chromosome 9 and a single human chromosome 19 are described. Neither of the plating techniques are superior to the other, as inferred from the insignificant differences in bony union, elbow function and complications between the two plating techniques. To examine trajectories of functional recovery after rehabilitation for traumatic brain injury (TBI). Our results demonstrated that altered glycosylation affected the interactions between oligosaccharides and the I-like domain, which in turn changed the accessibility of the specificity-determining loop for ligand binding. We discuss briefly the current evidence on pathogenesis of melanosis arising from metastatic melanoma.

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The purposes of this study were: (1) to compare microvascular leakage (MVL), cerebral blood volume (CBV), and blood flow (CBF) in the distinction of metastasis from GBM using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging (DSC-MRI), and (2) to estimate the diagnostic accuracy of perfusion and permeability MR imaging. In the recent years conservative functional treatment increasingly became the method of choice due to final results of the treatment.

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Further, this method complements experiments that can be carried out with a labeled selective ligand, since it emphasizes the contribution of the sites for which the selective ligand has low affinity. The aim of our study was to compare healthcare-related costs of treatment with XELOX and FOLFOX4 chemotherapeutic regimens in patients with colorectal cancer. Small clusters of hematopoietic cells that are independent of the vasculature (referred to here as extravascular islands) were shown to form in the mesentery during vascular remodeling of the vitelline artery. The progressive interstitial fibrosis with tubular atrophy seen in these patients has been ascribed to the slimming therapy preceding the pathology.

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In the present study, we sought to provide an improved measure of conceptual implicit memory by minimizing contamination from explicit retrieval. Designing simulator tools for rail research: the case study of a train driving microworld. Processing of amyloid precursor protein (APP) is a well acknowledged central pathogenic mechanism in Alzheimer disease. A patient with platypnea and orthodeoxia after right pneumonectomy is described.

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The nanoparticles characterized by scanning electron microscopy, powder X-ray diffraction, transmission electron microscopy, an energy dispersive X-ray spectrometer and UV-Vis DRS spectra. Influence of drying temperature on film structure and functional properties. The binding domain is a single-chain antibody fragment (scFv) derived from the monoclonal anti-high molecular weight-melanoma associated antigen antibody 763.74 by phage display techniques. Individual-level outreach program data can be used to estimate HIV incidence and intervention uptake among FSW in Zimbabwe.

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mansoni cercariae and different parasitological/immunological parameters were assessed seven weeks post-challenge. Similar to that from bacterial and mammalian sources, spinach leaf NTR was a flavoprotein (Mr 68,000) composed of two subunits of identical molecular mass (Mr 33,000) that resembled Escherichia coli NTR immunologically. In recent years, diffusion tensor imaging (DTI) has emerged as a promising tool to study ischemic stroke. Gestures produced by speakers with more severe aphasia were less informative than those by speakers with moderate aphasia, yet they were not necessarily uninformative.

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PDC is a frequency domain counterpart of Granger causality and has become a very prominent tool in EEG studies. Based on the current literature, an effective multifaceted fall prevention program for nursing home residents should include risk factor assessment and modification, staff education, gait assessment and intervention, assistive device assessment and optimization, as well as environmental assessment and modification. Developmental changes in serum ferritin concentration of dairy calves. The purpose of the current study is to provide recent (2013-2014) data on the prevalence of regular e-cigarette use in a population of recruits prior to their entry into the U.S.

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Here, by complementing a null FA-P Fanconi anemia cell line with SLX4 mutants that specifically lack the interaction with each of the nucleases, we show that the SLX4-dependent XPF-ERCC1 activity is essential for ICL repair but is dispensable for repairing TOP1 inhibitor-induced DNA lesions. Rosuvastatin inhibits pressure-induced fibrotic responses via the expression regulation of prostacyclin and prostaglandin E2 in rat renal tubular cells.

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A photoconvertible variant allowed time-resolved optical highlighting for PPI kinetic analysis. The physicochemical and electrical properties of Pd-deposited WO3 thin films were investigated as a function of Pd thickness, annealing temperature, and operating temperature for application as a hydrogen gas sensor. Healthcare managers who strive to improve the timelines of non-elective orthopaedic surgeries may benefit from using simulation modelling to analyse different strategies to support their decisions.

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Secondly, by mapping the DEGs and DEmiRs to the curated miRNA-TF-gene regulatory network as active seed nodes and connect them with their immediate neighbors, we obtained the potential active miRNA-TF-gene regulatory subnetwork in obesity. The use of radioactive isotopes in the study of peripheral vascular disease. While verapamil failed to reduce infarct size when the drug was given at the onset of reperfusion, similar effects of low dose diltiazem are not known.

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Furthermore, the spike times shifted earlier with increasing offset. Improvement of PCR amplified DNA sequencing with the aid of detergents. Prevalence and factors associated with malaria parasitaemia in children under the age of five years in Malawi: A comparison study of the 2012 and 2014 Malaria Indicator Surveys (MISs). Frozen-section analysis (FS) of the sentinel lymph node (SLN) is performed to avoid reoperation for axillary lymph node dissection (ALND), but it can miss micrometastatic disease, is labor intensive for the pathologist, and does not alter the number of breast-conservation therapy (BCT) patients needing reoperation for positive margins.

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Interstitial pneumonia can lead to acute respiratory failure, sometimes gradual deterioration of respiratory function, and pulmonary fibrosis progressing to respiratory failure. Cutaneous squamous/basal cell carcinomas have also often been reported following long-term administration of HU. Orbital perforating branch of the infraorbital artery: an important landmark in orbital surgery. The clinical significance of frontal intermittent rhythmic delta activity (FIRDA).

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Dyskerin is one of the three subunits of the telomerase ribonucleoprotein (RNP) complex. In this study, the anisotropic diffusion filtering technique was used to de-noise emission images and attenuation maps of a whole body for improving the quantitative accuracy of emission images. This article describes a technique to enhance a pontic site in the anterior maxilla by using forced eruption as an alternative to conventional hard and soft tissue augmentation surgeries. This study aimed to examine the relationship between sonographic diagnosis of fatty liver and liver enzyme level with histopathologic abnormalities and liver biopsy findings in patient with the nonalcoholic fatty liver disease (NAFLD). Across two laboratories we consistently found no correlation between these two scales.

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As a nanotechnology has been actively applied to the overall areas of scientific fields, it is necessary to understand the characteristic features, physical behaviors and the potential effects of exposure to nanomaterials and their toxicity. GnRH-I receptor protein expression was inhibited by using the antisense knockdown technique. At the end of a transcriptional response, alterations in histone acetylation status are reversed, but the dynamics of this process are poorly understood. To construct the recombinant adenoviral vector which can efficiently inhibit mature miR-21 expression and explore its effects and the underlying mechanisms on hepatoma cell line HepG2.

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There is still little consensus among authors about diagnosis and treatment of these serious condition, in particular about the ICP at which fasciotomy is absolutely indicated and the timing of wound closure. The decrease of HRV in the MF band in both groups suggests that the relative insensitivity of subjective mental effort scales among Indonesians has to do with how workload is reported rather than with how it is experienced.

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The connectivity domain can be constructed from any technique that identifies sets of features that are similar across subjects and can greatly help researchers in the study of macro-connectome brain function by enabling us to perform a wide range of model-based and data-driven approaches on rsfMRI data, decreasing susceptibility of analysis techniques to parameters that are not related to brain connectivity information, and evaluating both static and dynamic functional connectivity of the brain from a new perspective. Thrombocytosis is more frequently in patients with metastatic RCC but only showed significant influence on survival of localized RCC patients. Eight patients were exposed to opiates, five to both tramadol and opiates, three to other analgesics, and one to no analgesics. Growth and mature organization of brainstem, cerebellar, and hippocampal implants. Authors report data from 48,794 deliveries in Semmelweis University, I.

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During last years, multiple possible mechanisms involved in this association were identified. Value and limitations of systemic administration of griseofulvin.

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The endothelial cells of the sinusoid lining were perforated by increased numbers of large fenestrate which may be a reflection of elevated intrasinusoid pressures generated by the expanded arterialization of the sinusoid bed. Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes. Cytogenetic and blastomogenic effects of 45Ca and 131I administered to rats

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EFS reinstated extinguished cocaine- but not food-reinforced responding. Self-efficacy and behaviour as predictors of subsequent behaviour in an Assertiveness Training Programme. To confirm these results in a natural setting, we examine the assembly of endogenous complexes in mammary epithelial cells after release from a G(0) arrest. Transfusion-associated hyperkalemic cardiac arrest is a serious complication in patients receiving packed red blood cell (PRBC) transfusions. Four relevant noises were selected: a multi-talker babble, the noise in an industrial plant, in a printing office and a city-noise background.

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Preliminary evaluation of technetium-99m-labeled ceftriaxone: infection imaging agent for the clinical diagnosis of orthopedic infection. One approach in UTI control could be the use of lactobacilli because these indigenous inhabitants in human intestine have been found to play an important role in protecting the host from various infections.

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HSC clones were obtained from unseparated bone marrow (BM) through limiting dilution approaches. Stuttering behavior and anxiety as a function of experimental training. Increased frequency of follicular helper T cells in mice viral myocarditis is relevant with anti-ANT antoantibody.

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XRD results indicated that no remarkable change in the cellulose crystallographic form of the BC samples. Developmental Screening and Referrals: Assessing the Influence of Provider Specialty, Training, and Interagency Communication. The HSTF is present in both heat-shocked and nonshocked cells, although it is more transcriptionally active when isolated from heat-shocked cells.

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We found ((1)VCKKITEHERCHVNI(15)), ((20)AFFGVMPRGTTPRAPVR(36)), ((46)RRGLETGWAYTHQGGI(61)), ((281)EGDMATGITYASYGYFC(297)), ((426)YSGEDPANLRVVTSQSPYVVVATNAIESGV(455)) and ((481)FIVTGLKRMAVTVGEQA(497)) can be recognized by the BVDV infected bovine serum. Although the resulting hippocampal-related functions were similar in OE and KO mice following cranial irradiation, molecular analyses suggested that they may be governed by different mechanisms: whereas neurotrophic factors may influence radiation responses in OE mice, dendritic maintenance may be important in the KO environment.

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It was established that the females predominated in that group--20 out of 23. Taken together, these data indicate that the up-regulated microglial Cat H expression, release, and activity in the brain lead to neuronal death in neuroinflammation. Plasminogen activator inhibitor-2 is expressed similarly in both cell types.

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Distinct pathogenic sequela in rhesus macaques infected with CCR5 or CXCR4 utilizing SHIVs. LAC was determined according to the Subcommittee on Lupus Anticoagulant/Phospholipid Dependent Antibody guidelines. Genome-wide association analyses for boar taint components and testicular traits revealed regions having pleiotropic effects. We included all original articles in which both physical activity and asthma were assessed in case-control, cross-sectional or longitudinal (cohort) studies. To further validate these reports, we defined a set of liberal criteria for preoperative IABP insertion and applied them to a series of elderly patients (70 years or older) undergoing isolated coronary artery bypass grafting.

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Women with postpartum haemorrhage (PPH) in developing countries often present in critical condition when treatment might side effects of topiramate 25 mg tablets be insufficient to save lives. Negative chrono- and inotropic responses to both carbachol (CCh) into the sinus node artery and electrical stimulation of vagal nerve fibres (ES) were studied in the isolated, blood-perfused canine right atrium, using four muscarinic receptor antagonists, atropine, 4-DAMP, AF-DX 116 and pirenzepine. Free ecdysteroids were detected in the serum of ferrets and dogs infected with D. Selective Aerobic Oxidation of 5-(Hydroxymethyl)furfural to 5-Formyl-2-furancarboxylic Acid in Water. Clostridium difficile is the most common cause of antibiotic-associated nosocomial infection in the United States.

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Constitutive bcl-2 overexpression increases the tumorigenic and metastatic potential of doxorubicin-resistant, estrogen-independent, MCF-7 ADR human breast cancer cells. Second, genetic research has dealt only with the presence of depression and taking account of course may radically change ideas about the point at which G x E occurs. Deposition of serum proteins in vascular walls during acute hypertension. The use of biochemical markers of bone resorption and formation to evaluate the risk of viratop apotex pharmaceuticals skeletal disease and its response to treatment also requires further study.

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The difference in WM activity after practice predicted performance cost in controls but not in patients. The authors present three patients with recalcitrant, venous and mixed venous, and arterial leg ulcers treated with these dressings. mosi ticket price Finegoldia magna is an anaerobic Gram-positive bacterium and commensal, which is also associated with clinically important conditions such as skin and soft tissue infections.

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Efforts to promote awareness should be targeted at men, what does pantoprazole sodium dosage older people and uneducated individuals. Patent ductus arteriosus with progressive dilatation of the pulmonary artery. To elucidate whether human primary gastric cancer and gastric mucosa epithelial cells in vitro can grow normally in a methionine (Met) depleted environment, i.e.

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Significant effects with respect to directionality were observed in Erector tab synclar Spinae muscles. The aim of this study was to investigate (i) whether integrating a course on crisis resource management principles and team debriefings in simulation training, increases self-efficacy, team efficacy and technical skills of nursing students in resuscitation settings and (ii) which phases contribute the most to these outcomes.

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A retrospective review of all skin biopsies received and reported by the Department of Pathology, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia between January 2005 and December 2010. The etiology of the valve lesion was determined by assessment absetzerscheinungen bei cymbalta and alcohol of the clinical history, chart review, gross morphology, and valve histology.

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Surgical-pathological findings in type 1 and 2 endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study on GOG-210 protocol. For years, the owners had been feeding bidrostat 50 mg large quantities of pet jerky treats containing chicken prepared in China.