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A systematic review and meta-analysis aimed to identify all randomized clinical trials (RCTs) of NRT versus inert controls and all observational studies to determine the magnitude of reported adverse effects with NRT. Recently, several histone demethylases have been identified that catalyze the removal of methylation from histone H3 lysine residues. Considerable evidence indicates that the amygdala plays a critical role in negative, aversive human emotions. After establishing relevance from the abstract, the entire paper was read, and the significant points included in the review.

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