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Because rodents lack Kal1 in their genome and have GnRH neurons scattered throughout their forebrain, the development of forebrain GnRH neurons and the pathogenesis of X-KS have been difficult to study. This paper provides a brief overview of the AOPs related to reproductive and developmental toxicity currently available in the AOP Wiki (, and gives an example of an AOP network based on five reproductive and developmental toxicity-related AOPs for fish to illustrate how AOP networks can be used for assay development and refinement. Ablation of neurogenesis attenuates recovery of motor function after focal cerebral ischemia in middle-aged mice.

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Compounds 2, 6, 8 and 9 are obtained from the Artemisia genus for the first time. The MG pvpA sequences were found to be highly variable with a discrimination index of 0.975 for Russian field samples. Interpatient variability, particularly of duration of drug action, may exist in the neuromuscular response to the administration of doxacurium in dogs. Sources of contamination by polycyclic aromatic hydrocarbons in Spanish virgin olive oils.

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Since electrical stimulation of the PVN or the systemic administration of arginine-vasopressin (AVP) result in a depression of the nocturnal melatonin surge, this neuropeptide appears to be pivotal for the transduction of PVN-efferent, pinealopetal signals. The significance and genesis of hematoxylin-staining bodies in the human testis. A growing body of evidence, however, indicates that such a recruitment strategy does not always hold true. The assumption that patients can be spared hypophyseal insufficiency only holds for small tumors. Purification studies on a thermo-active amidase of Geobacillus pallidus BTP-5x MTCC 9225 isolated from thermal springs of Tatapani (Himachal Pradesh).

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A new method of osteosynthesis in proximal humeral fractures: a new internal fixation device. The aim of this work was to develop effective fast-dissolving tablet formulations of glyburide, endowed with improved dissolution and technological properties, investigating the actual effectiveness of the Solid-Self MicroEmulsifying Drug Delivery System (S-SMEDDS) approach. As outcome measures, the Numerical Pain Rating Scale, short-form McGill Pain Questionnaire 2, prazole plus drug study scribd free EQ-5D-5 L, Hospital Anxiety and Depression Scale, 10-Item Perceived Stress Scale, Insomnia Severity Index, and Patient Global Impression of Change will be completed at baseline, weekly for the duration of the study and at 1 month after completion of the study.

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