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Piramax (Topiramate)
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Topiramate

Piramax is the brand name of Piramax, an anticonvulsant drug used to prevent seizures and reduce the frequency of migraines. While its exact mechanism of action is unknown, studies suggest Piramax might alter the production or action of neurotransmitters in the brain, suppressing the abnormal activity of the nerves in the brain that cause seizures or preventing the abnormal activity from spreading to other nerves. Other research has suggested that it might suppress the nerves directly, thereby making them less likely to fire. The Food and Drug Administration (FDA) approved Piramax to treat seizures in 1996.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Consistent with a cross-regulation between AMPK and mTOR to control food intake, our data show that the activation of these enzymes occurs in the same specific neuronal subtypes. We conducted a retrospective study evaluating patients with solid pancreatic lesions in whom EUS-FNA was performed.

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Prenyltransferases attach the isoprenoid lipids to the C-terminus of several small guanosine triphosphate-binding proteins. Malarial anaemia and anaemia severity in apparently healthy primary school children in urban and rural settings in the Mount Cameroon area: cross sectional survey. Further in vivo and human studies of 4-META/MMA-TBB resin as a dental luting agent are warranted.

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Even though the deviation is similar for both mutants, the curvature of the P-loop faces the opposite direction. These data show that the tumor had approximately 6.5 times the number of binding sites as did the normal Copenhagen rat dorsolateral prostate gland. At 8 hr after endotoxin (2.5 mg/kg), immunoreactive IL-1 alpha was observed in the same areas and cell types as IL-1 beta. Diammine dicarboxylic acid platinum (DDAP), a novel polymeric platinum compound, was developed by conjugating the platinum analogue to aspartate-chondroitin for drug delivery to tumor cells. The BAL fluid concentrations of protein, albumin, total iron, lactoferrin, ferritin, transferrin receptor and total iron binding capacity were measured.

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The mortality experience of 10,322 men employed in woodworking industries was compared with that of 406,798 nonwoodworkers. Microsurgical Penile Replantation after Self-inflicted Amputation in a Schizophrenic Patient: 5-year Follow-up.

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Polypeptide aggregation into amyloid is linked with several debilitating human diseases. Despite this curative approach, a significant subset of these patients will develop locoregional failure and/or distant metastases. The most abundant family and the most dominant pollen was Cistaceae. In addition, increased plant growth and C/N ratios of pine needles at elevated CO(2) resulted in an increase in cation exchange capacity (CEC) and dissolved organic carbon (DOC) of the rhizosphere in Pb contaminated soil.

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The clinical and prognostic significance of micrometastatic disease discovered by cytokeratin immunoperoxidase reactivity in the previously pathologically N0 neck is also evaluated. Designing enzyme-like catalysts: a rhodium(II) metallopeptide case study. Free and bound histamine in kidney parenchyma in experimental nephritis Capromab pendetide imaging can localize early PSA recurrence and may guide appropriate treatment after patients undergo radical prostatectomy.

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Inadequate physician training may be a barrier to physician-patient discussions of advance directives (ADs). NAP amplitude and velocity decrease over successive cycles of anoxia at a rate greater than in the absence of anoxia.

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The treatment estimators are examined for unbiasedness and efficiency. CT provides a site-related measure of the bone mineral density in the mandible and appears potentially useful as a non-invasive method to determine a parameter that may reflect bone quality prior to implant placement. In this study, 321 drivers, who on average 3.4 years earlier had completed a pre-license driver-training program in a medium-fidelity simulator, responded to a questionnaire about their on-road driving.

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Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections constitute a major global health problem. In fact, these selective specific antimigraine drugs are an advance in acute migraine treatment. The steady-state kinetics of SGD with a variety of strictosidine analogs revealed the substrate preferences of this enzyme at two key positions of the strictosidine substrate.

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A cross sectional study of markers of hepatitis B infection in Niue. Atherosclerosis (AS) is the number one killer in developed countries, and currently considered a chronic inflammatory disease. Receiver-operating characteristic and area under the curve (AUC) analyses allowed comparisons of the discriminative properties of these biomarkers to be made at their optimal cut-off points.

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The problem of designing efficient combined chemotherapies is formulated as an optimal control problem and tackled using a state-of-the-art evolutionary algorithm for real-valued encoding, namely the covariance matrix adaptation evolution strategy. To investigate the medium-term evolution of grey matter (GM) damage in patients at presentation with clinically isolated syndrome suggestive of multiple sclerosis (MS), and to assess whether it is associated with clinical disease activity during the initial stage of MS. Their possible functions as carriers for hormones and metals, in the coagulation system, and in immunological protection of the fetus from the maternal homograft rejection mechanism have also been investigated. Aggressive resection provides survival benefit and a better quality of life.

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Impact of HIV-1 genetic diversity in China on the measurement of viral load. New detection system for toxic agents based on continuous spectroscopic monitoring of living cells. A potentially important additional finding was the presence of degenerative lower cervical spine disease in the majority of patients.

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If the numbers of iNKT cells are not correctly regulated it can result in autoimmune disorders, such as diabetes. Six months after the final ranibizumab injection, a more-or-less complete resolution of the exudative retinal changes was observed. A prospective longitudinal cohort study of laboratory-confirmed adult patients with bacteremia was undertaken at a public hospital in Santiago, between June 1, 2007 and April 30, 2008. Rosiglitazone and cardiovascular risk: weighing recent evidence. According to our results, image intensifier time should not exceed 3 minutes in ESIN of femoral shaft fractures and 2 minutes in ESIN of lower-leg fractures.

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Interaction between p53 codon 72 polymorphism and melanocortin 1 receptor variants on suntan response and cutaneous melanoma risk. However, the patterns of viral infection and the effects on hearing have not been directly compared between these two approaches. Tailored mesostructured copper/ceria catalysts with enhanced performance for preferential oxidation of CO at low temperature. We discuss the anatomic, imaging, and otologic aspects of ICA aneurysms in this location. A precise diagnosis is of paramount importance because of the bad prognosis of this disease, and because there is a broad therapeutic armamentarium which can significantly modify the disease process.

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C35 (C17orf37) is located on the HER2 amplicon, between HER2 and GRB7. Lymph node metastasis from ovarian cancer in the 1st stage in relation to the histological type of the tumor

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The purpose of this study was to investigate the footstrike patterns among novice runners. Hence, extended colonic resection (ECR) is often performed and considered generally in young patients. It was discovered that the embryos were dying at the stage of the operating procedure at which ink was being introduced under the embryo. Tissue-specific expression of Tirant was detected in the tissues of ovaries in a strain mutant for the flamenco locus.

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No instrument-related complications were seen with our new instrument set. The electrophoretic examination of serum: a comparison between moving boundary and zone electrophoresis. Study summarises the life, work, pedagogical and popularization activities of Josef Thomayer on the basis of his publications and writings as well as archival sources. There were significant reductions in the following variables after both treatment periods: total phospholipids, total triglycerides, HDL-phospholipids and apolipoprotein A1. The way to remission from chronic depression: a psychopathological consideration

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Both type A and B were detected in the peripheral blood B-lymphocytes (PBL) from 1 healthy individual. davidii appear associated with climatic oscillations, topography and eco-environmental variation of China. In addition, a greater amount of L55P TTR bound with high affinity to membranes made from anionic phospholipids, phosphatidylglycerol (PG) and phosphatidylserine (PS), than to membranes made from zwitterionic phospholipid phosphatidylcholine (PC).

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Fragmentation patterns were discerned via consecutive MS/MS experiments on an ion trap mass spectrometer and confirmed by high-resolution (HR) Fourier transform ion cyclotron resonance MS. These included differences in the relationship between mass synthesis and cell division, the utilization of nonlimiting nutrients, and the nature of changes in energy metabolism. The ULAM is based on 24h ambulatory monitoring of body segment accelerations and enables valid and objective quantification of mobility and upper limb activity in transversal studies.

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They contain cytoplasmic actin, small amounts of alpha actin, and alpha actinin but are devoid of tubulin, myosin and vimentin. However, in patients with highly active disease or ileal disease with distal colonic manifestation higher doses of budesonide could increase the therapeutic response Blood cell appearances were similar to those reported for adult Indian river buffalo though values recorded for red cell components were higher. To address the consequences of short-term increase in E2F1 activity in adult tissues, we generated transgenic mice expressing the human E2F1 protein fused to the oestrogen receptor (ER) ligand-binding domain.

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Dopamine-1 receptor agonist: renal effects and its potential role in the management of radiocontrast-induced nephropathy. Conjugative transfer and cis-mobilization of a genomic island by an integrative and conjugative element of Streptococcus agalactiae. Toll-like receptor 3 agonist polyinosinic-polycytidilic acid (poly I:C) has been widely used as a potent adjuvant in tumor immunotherapy. This analysis evaluated the impact of a hospital-acquired IC after open abdominal vascular surgery on the readmission rate and the mortality rates 30 and 90 days after initial discharge.

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Overall, these results suggested that AST might protect cells against glutamate-induced apoptosis through maintaining redox balance and inhibiting glutamate-induced calcium influx and ER stress. The prevalence of rare mutations in candidate genes in subjects with primary HTG is low. In the young and young adult rats both Cere and E021 treated rats showed shorter escape latencies than saline treated controls on all 6 test days. IGFBP-6 nuclear translocation was an active process that required importins. We illustrate our empirical validation of these indicators using the examples of peptic ulcer and renal failure.

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Residual stumps associated with inguinal varicose vein recurrences: a multicenter study. While a high rate of peritonitis predisposes to technique failure, we found no features at baseline predictive of patients at greatest risk to fail PD.

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The alpha isoform is involved in chromosome condensation and segregation, whereas the role of the beta isoform is not yet clear. The transfer was used in conjunction with samples for which data was recorded online for the partial least squares regression of volatile solids, ammonium, total inorganic carbon, and volatile fatty acids parameters in the fresh matter of a digester slurry. Little is published in the scientific literature about the interrelation of environmental factors and possible unintended effects in genetically modified (GM) plants. There was considerable heterogeneity between tumors prior to radiation. A modified approach to the procedure of fistulotomy is discussed.

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The failure to reconstitute telomerase function in planta suggests a more complex telomerase regulation in plant cells than would be expected based on results of similar experiments in mammalian model systems. Two major factors associated with long patient stays on the Geriatric Evaluation Unit were low functional status scores and not living in own home or with family. All patients showed extrafoveal schisis within the outer and inner nuclear and ganglion cell layer, alone or in combination. Non-target impact of fungicide tetraconazole on microbial communities in soils with different agricultural management. Studies on the substance related to RNA in Mycobacterium tuberculosis.

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Mortality and recovery from refractory status epilepticus in the intensive care unit: a 7-year observational study. Patients with distal emboli or contraindications to operation should be treated by anticoagulant therapy, alone or with local fibrinolytic treatment. It is not yet clear how acute and chronic sleep loss modify neuronal activities and lead to adaptive changes in animals. One of the patients was a human immunodeficiency virus type 1-seropositive man, and the enterovirus infection was the first clinical manifestation. Life course measures of socioeconomic position and self reported health at age 50: prospective cohort study.

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Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. The patterns of protection suggest bending of the triple helical peptide partly around the catalytic domain to reach novel exosites.

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To assess the impact of mechanical debridement of subgingival biofilm on periodontal outcomes in adolescents and young adults with asymptomatic third molars. Serious viral CNS infections during childhood appear to be associated with the later development of schizophrenia and nonaffective psychoses. Expression profiling of vascular tissues allows the simultaneous analysis of thousands of genes and may provide predictive information particularly useful in early disease stages. Role of chemotherapy using antibiotics as a radical treatment of uterine carcinoma

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Heat treatment has long been regarded as one of the most widely used and most effective means of destroying pathogens in food. They are better recognized with modern diagnostic techniques and can be more easily classified and thus treated. And inflammatory cytokines, such as interferon gamma, tumor necrosis factor alpha, and anti-inflammatory cytokine transformation growth factor alpha, further increased the ability of RM-1 to produce PDGF-BB. Endoscopically, the tumor mass protruded into the gastric cavity at the antrum and ranged from 4.5 cm to 8.0 cm in greatest dimension.

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This article describes pathophysiological mechanisms involved in the defective uteroplacental vascularization leading to placental and endothelial dysfunction. Furthermore, GAD67 mRNA localization spatially was more correlated with GAD protein expression.

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A paper-chromatographic method for the determination of suitable buffer systems for countercurrent distribution. A single 3D echo planar imaging (EPI) prescan is sufficient to obtain the necessary coil sensitivity information and reference images that are used to reconstruct standard images, so that standard analysis methods are applicable. Enhanced recovery protocol could be a useful tool to reduce patient morbidity and reduce length of inpatient stay. Induction of ferritin synthesis by iron in liver as well as red cells combines high translational efficiency with increased utilization of preformed ferritin mRNA. One showed exacerbation of undisclosed leprosy after transplantation.

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Raman area mapping and single-point measurements show noticeable changes in the D-band, G-band, and 2D-band signals of the SLG during consecutive electrical programming repeated for nine cycles. The relative contribution of each component of the buccal mucosa on drug permeability was assessed in this study.

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To obtain insight in the extent of expression of inhibitory regulators of immunity in patients with active TB, peripheral-blood-mononuclear-cells (PBMCs) and plasma were obtained from 54 TB patients and warfarin drug disease interactions in the elderly 29 healthy blood donors from Chittagong, Bangladesh. Appropriate counselling, including possible adverse drug reactions and dosing directions, is important for parents and children at both the prescribing and dispensing of medicines for paediatric patients.

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Using two nexpro rd 20 tablet cases exemplar experiments, this paper introduces an approach to include both the lexical decision task and the naming task in a study. Few data are available on the outcomes of pediatric antiretroviral therapy (ART) in the developing world. marxianus, determined by the number of residues of a single hydrophobic residue located between N-terminal basic and C-terminal acidic amino acid boundaries.

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The present investigation explores face emotion recognition (FER) performance throughout the course amoxi-clavulan stada erfahrungen anyoption of schizophrenia. The objective of the study was to describe the molecular genetic findings in a family affected by hypophosphatemic rickets with presumed autosomal dominant inheritance. Epidemiologic evidence suggests that hepatic adenomas are etiologically related to oral contraceptive use, whereas focal nodular hyperplasia does not seem to be caused by these agents. New aptamer drugs are being approved for clinical evaluation, and it is certain that we will see increasingly more aptamers and aptamer-like drugs in the future.

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There is considerable published evidence to support nasal dysfunction associated with exercise, and a link to lower airway dysfunction. These findings suggest that MRI loxone vs siemens logo manual pdf may provide a noninvasive means of quantitatively analyzing the volume and spacial distribution of repair tissue in osteonecrotic femoral heads. A generation of clinicians was trained at these research centres where the bulk of US HIV patients were treated.

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Critical look at the legalization of the liberal use of high-dose narcotics: is duralast 600 amp jump starter review this a reality? Members of the fibroblast growth factors induce ectopic neural plate formation in cultured chick embryos. Compared to orthopedic studies radiotherapy data are lacking long-term analysis and objective reproducible evaluation criteria.

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Natural antisense transcripts (NATs) as one of the most diverse classes of long noncoding RNAs (lncRNAs), have been demonstrated involved in fundamental biological processes in human. Natural killer cell dependent within-host competition arises during multiple MCMV infection: consequences for viral transmission and evolution. Pilot study in teaching hematology with emphasis on self-education by the students. These results indicate that the gills and viscera are able to spread the pathogens to fish meat as well as fish surface contamination by washing in citara songs for kids the contaminated seawater. The results show that the main emission properties were modified by varying the CoSi(2) thickness and that stable, low-field, high emission current and controlled electron emission can be obtained by using a high quality diamond film and a thicker CoSi(2) interlayer.

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Test-Retest of Long Latency Auditory Evoked Potentials (P300) with Pure Tone and Speech Stimuli. From a clinical perspective the results highlight vermazol dosage the need for multidisciplinary support programs to promote a more realistic illness perception.

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From a public health perspective, both behaviors are unwanted, and populations that are at risk are often at high risk for both. Outcome measures will be assessed before and after the 6 month intervention period. The current review summarizes the findings of recent studies using genetic and genomic approaches to understand the underlying molecular mechanisms of ASD. Nevertheless, in some patients late myelopathy can ensue even in the absence of identified causes. Specific imidazolone immunoreactivity was detected in nodular lesions and expanded mesangial matrix of glomeruli, and renal spironolacton 1a pharma 50 mg arteries in an advanced stage of diabetic nephropathy, as well as in atherosclerotic lesions of aortas.