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The epidemiological transition model describes the changing relationship between humans and their diseases. Here, we describe the development and products of the ontological approach to phenotype capture, the formal content of phenotype ontologies and how their content can be used computationally. The purpose of this study is to correlate common radiographic findings with observed intra-operative pathology in patients with plantar plate pathology.

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It was found that fatty replacement of paraspinal muscles is a normal age-progressive phenomenon most prominent in females. We designed a prospective, double-blind, randomized controlled study to determine the effects of intraoperative dexmedetomidine on postoperative recovery including pain, sedation, and hemodynamics in pediatric patients undergoing tonsillectomy and adenoidectomy. In the post-lysis period these patients are at high risk for recurrent ischemic events. The aim of this study was to examine the impact of the esophageal flexion level on the clinical condition and surgical outcomes of patients with sigmoid esophageal achalasia. In 517 patients without RVT and with negative D-dimer, anticoagulation was stopped and D-dimer was repeated after one and three months.

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Regional maximal vascular capacity was measured during nitroprusside-induced vasodilation, using radioactive microspheres. No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population. These patients were matched according to age, sex, body mass index, and stone side, size, site, and number of stones per patient, with patients who had been prestented before URS.

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Problems arise when we use these methods, such as the selection of a suitable threshold value for the histogram-based method and the over-segmentation followed by the time-consuming merge processing in the region-based algorithm. To perform a systematic review of the contrast behaviour of HCC on Gd-EOB-DTPA hepato-biliary phase MRI.

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DDC mRNA levels were lower in squamous cell carcinomas (SCCs) of the larynx and tongue than in adjacent non-cancerous tissue specimens. Our results in study one show that A-FABP serum levels are positively associated with body weight and fat mass. Activating mutations of BRAF and KRAS were identified and correlated with promoter methylation of 11 loci, including MINT1, MINT2, MINT31, CACNA1G, p16(INK4a), p14(ARF), COX2, DAPK, MGMT, and the two regions in hMLH1 in 468 CRCs and matched normal mucosa.

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The obtained results showed that IBD causes an increase in the number of nitrergic nerve fibers in all intestinal segments studied and these changes are directly proportional to the intensity of the disease process. Papillary and follicular thyroid carcinomas shared the expression of simple epithelial-type CKs 7, 8, 18 and 19. Male patients exceeded female (2:1) and 65.7 percent were below 30 years of age. Many of these candidates are derived from repeat regions, yet they seem to contain the features necessary for correct processing by the miRNA machinery.

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Continuing medical education, improvement in social and medical amenities and the national health insurance scheme are possible ways of overcoming undue delay in presentation for specialist consultation. The most common of these diseases is bullous pemphigoid, which mainly affects older people and the reported incidence of which in Europe has more than doubled in the past decade. To assess objectively the efficacy of migraine without aura treated by comprehensive auricular acupuncture. Cells overexpressing PTEN demonstrated decreased phosphorylated (active) AKT and AKT kinase activity compared with controls.

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The serum polysaccharide level in malignancy and in other pathological conditions. Agonists, neutral antagonists, and inverse agonists all promoted increases in BRET values for MT2R but not for MT1R homodimers in living cells and isolated plasma membranes.

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Integration of clinical and basic sciences in concept maps: a mixed-method study on teacher learning. After reaction with a methanethiosulfonate spin label, the principle values of the hyperfine tensor A and the g-tensor were determined from electron paramagnetic resonance spectra measured at 170 K.

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The overall prevalence of complementary medicine (CM) use among adults in the United States with diabetes has been examined both in representative national samples and in more restricted populations. Currently, there are no viable therapeutic options for patients with plexiform neurofibromas that cannot be surgically removed because of their proximity to vital body structures.

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Disconnection was done in emergency using a total ligature of the oesophagus by left thoracotomy upon a clip introduced by oral way. This study provides evidence of the importance of the central nervous system in the pathogenesis of hypertension produced by systemic mineralocorticoid excess. These findings suggest the existence of secretory forms of cAMP-dependent protein kinase R- and C-subunits and their separate regulation. Usefulness of the polymerase chain reaction for monitoring cure of mice infected with different Trypanosoma cruzi clonal genotypes following treatment with benznidazole. The continence rate was the same, with 2 cases of incontinence in each group.

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Anti-inflammatory activity of lycopene isolated from Chlorella marina on type II collagen induced arthritis in Sprague Dawley rats. Before clinical application in myopic patients, a study in an animal myopia model is recommended. In contrast, patients with localised PCa and low PSA derived no survival benefit from early bicalutamide.

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4 Higher doses of both oximes showed significantly more effective therapeutic efficacy against all nerve agents studied. Brief report: assessment of development and abnormal behavior in children with pervasive developmental disorders. The reversed size effect on intercalation probably was not caused by crystallinity differences as reported in the literature, because the Hinckley and Lietard crystallinity indices of the four clay fractions were very close to each other. The duct in the tail area showed the best results, which suggested the importance of preservation of the pancreatic tail.

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The three-fold channels, the putative ferroxidase sites, and the nucleation sites all show expectedly negative values of the electrostatic potential. Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Return of central estrogen action appears to cause the hypothalamic oxytocin pulse generator to alter its frequency and produce a series of intermittent episodes of oxytocin secretion. Transcriptional repression of pref-1 by glucocorticoids promotes 3T3-L1 adipocyte differentiation.

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In comparison with urea, it appears indefinitely stable in aqueous solutions and does not chemically modify proteins upon storage. The well-studied probiotic Lactobacillus rhamnosus GG ATCC 53103 (LGG) was administered in a clinical trial, and a suite of measurements of the resident microbes were taken to evaluate potential changes over the course of probiotic consumption. Metals contained in the waste transfer to the waste incineration products, including flue gas, fly ash, and bottom ash, as different oxide, nitride, carbides, and other phases.

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Cellular function prediction and biological pathway discovery in Arabidopsis thaliana using microarray data. In vitro, its uptake by multidrug resistant and non-resistant MES-SA tumor cells parallels that of 99mTc-MIBI, a well-characterized marker of multidrug resistance.

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Perihepatic metastases from ovarian cancer: sensitivity and specificity of CT for the detection of metastases with and those without liver parenchymal invasion. Our enhanced understanding of ovarian ageing will facilitate early identification of individuals at greatest risk, and novel therapeutic interventions. Volatile compound profiling of Turkish Divle Cave cheese during production and ripening. Human umbilical cord-derived PCs and MSCs exert short- and long-term therapeutic benefit without adverse lung effects in this experimental model and offer new therapeutic options for lung diseases characterised by alveolar damage.

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The patient had a morbidly enlarged tongue and presented with clinical signs and symptoms consistent with massive macroglossia. In gradients of attractant these sites are persistently present on the side of the cell facing the higher concentration, even in the absence of a functional actin cytoskeleton or cell movement. Causal network modeling is a systematic computational analysis that identifies upstream changes in gene regulation that can serve as explanations for observed changes in gene expression.

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There is an urgent need for effective vaccines against serogroup B Neisseria meningitidis. Determinants of appointment absenteeism at an outpatient pediatric autism clinic. It is recommended that repeat embolectomy be carried out and all mechanical causes for re-thrombosis be excluded before resorting to fibrinolysis.

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As this abbreviated, highly sensitive sequence requires a fraction of the acquisition time of conventional LS MRI, it has the potential of contributing to increased efficiencies in the radiology department and improved ED throughput. Easy-axis kagome antiferromagnet: local-probe study of Nd3Ga5SiO14. Resuscitation status of all inpatients on a single day was determined using interviews with nursing staff and examination of the nursing and medical case notes. Uses of BZ 55: a sulfonamide derivative for oral administration We present an overview of the results we obtained in our laboratory over the past few years.

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Anterior rhinoscopy revealed a mass arising from the inferior nasal concha on the left side. The validity of both data and approach, as well as the discrepancies between the direct and indirect methods, are discussed. All patients received concomitant temozolomide at a dose of 75 mg/m2 daily during radiation therapy. From the different response of Trp and Tyr residues, as monitored by fluorescence and 4th derivative absorbance changes, the C-terminal domain carrying all the Trp residues seemed to exert structural changes at relatively lower pressure.

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On biopsy, there were single, round and polygonal tumor cells with a striking plasmacytoid appearance infiltrating diffusely throughout the edematous lamina propria. Traumatic spondylolisthesis of the axis: analysis of management. Both cases are suspected to be the result of feral cats gaining access to the enclosure.

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Our findings are remarkably similar to recent numerical results on model thermal liquids and thus open an intriguing possibility of understanding the dynamic arrest in both thermal and athermal systems in a unified manner. Skin and gill extracts produced hydrogen peroxide, responsible for antibacterial activity, in the presence of l-lysine. Thus, metabolomics, besides transcriptomics or proteomics, provides a major tool for the characterization of postgenomic processes. 15 patients had gastrointestinal bleeding during follow-up, and the median survival time was 11.0 months. Statistical effects in the absorption and optical activity of particulate suspensions.

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Muscle mitochondrial ultrastructure in exercise-trained iron-deficient rats. These results suggest that cognitive functions are impaired in the mice infected with LP-BM5. The results show clearly that the apparent lag time is dependent on the size of the inoculum, especially when the inoculum is sublethally injured. The homeodomain transcription factor Prox1 is essential for development of the lymphatic system by specifying lymphatic endothelial cell (LEC) fate. Analysis of its pathophysiologic roles has been difficult because low concentrations of TNFalpha, including those in healthy controls, cannot be measured by existing methods.

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Since metal levels showed a consistent pattern in feathers and excrements of nestling great tits, we conclude that both represent good and non-invasive methods for the evaluation of these elements in polluted areas. Thus, we were able to determine the differential selectivity of IT for T cells as compared with stem cells in the same donor preparation.

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Seventy-four subjects from a multicenter clinical trial with lotrafilcon A lenses were queried on aspects of lens wear. S-stages of positive SN were correlated with the status of further metastases in the axillary lymph node basin after axillary lymph node dissection (ALND). In isolation procedures for lymphocytes, isotonic ammonium chloride buffers are frequently used to lyse erythrocytes. Estimating length of stay in publicly-funded residential and nursing care homes: a retrospective analysis using linked administrative data sets.

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The children rapidly developed severe psychomotor regression and cerebral atrophy. A chart review of 2567 live births of children of Inuit parents residing in Arctic Quebec (Nunavik) and on Baffin Island (Nunavut) between 1989 and 1994 (five years) was carried out compared to rates of anomalies of the Alberta Congenital Anomalies Surveillance System (ACASS). Only mutants with a deletion of PGM3 hyper-accumulated ribose-1-phosphate. Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia. Increasing by six-fold, the pore diameter leads to a 1.1 fold increase of the fractional exponent.

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These findings suggest that thrombin plays an important role in the pathogenesis of puromycin aminonucleoside-induced nephrotic syndrome. A slit-lamp eyepiece micrometer calibrated at 50-micron intervals. Retinal vessel caliber and the long-term incidence of age-related cataract: the Blue Mountains Eye Study. Plasma serotonin concentration was measured by HPLC, and tryptamine (TRP), tyramine (TYR), phenylethylamine (PEA), and isoamylamine (IAA) were measured by liquid chromatography-mass spectrometry. The implantation window could be maintained for at least 48 hours by 5 mg TP per mouse.

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A case of recurrent digital ischemia due to thrombosis of the persistent median artery is presented. Localizing value of ictal SPECT is comparable to MRI and EEG in children with focal cortical dysplasia. Significance of retinoblastoma and mdm2 gene expression as prognostic markers for soft-tissue sarcoma.

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Colonic polyps and adenocarcinoma complicating ureterosigmoidostomy: report of a case. Heart failure (HF) patients with implantable cardioverter-defibrillators (ICD) require admissions for disease management and out-patient visits for disease management and assessment of device performance. Preparation of egg white lysozyme and proteins labeled with C-14 and H-3 In clinically suspicious infants for HD, those with inconclusive studies may benefit from a lower threshold to perform follow-up rectal biopsy.

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The P-V curves are compared to the surface pressure isotherms Pi-A that are measured using a Langmuir trough and a Wilhelmy plate on a flat water-decane interface covered with the same particles. We isolated essential genes from bacteria found in the Arctic and substituted them for their counterparts into pathogens of mammals.

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Restrictions on smoking in public areas may lead to less smoking and increased quitting. Three preparations of tumor were used in orthotopic transplantation to 5 sites on the eye and eyelid. Although adolescents in foster care are known to be more at risk for school-related academic challenges, there is a paucity of research on their school-related experiences, such as victimization and relationships with teachers, compared with their same-age peers not in care. Once swallowed by the patient, the capsule transmits images to an external recorder over a digital radiofrequency communication channel. Stress radiography in near extension revealed a highly significant increase in posterior tibial subluxation in the injured knees.

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Grade 2 and grade 3 ulcers received either medical therapy alone or medical therapy combined with debridement, amniotic membrane transplantation (AMT), or both. In this study, we demonstrated that a synthetic 44-amino acid peptide (44-mer) derived from pigment epithelium-derived factor (PEDF) can facilitate the production of a large number of actively dividing HPC from normal adult rat livers in a 35-day culture period.

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Abnormal Dimercaptosuccinic acid (DMSA) renal scintigraphy performed six months after an acute pyelonephritis (AP) is generally interpreted as scarring. We investigated the drug distribution and pharmacokinetics of 5-FU in rats receiving an i.p. Submucosal invasion was much longer in the oral direction than in the anal.

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The newly available catheter MESH was safe and effective to quickly isolate two reconnected PVs. Associations among nocturnal sleep, daytime intradialytic sleep, and mortality risk in patients on daytime conventional hemodialysis: US Renal Data System special study data. These results suggest that, besides P1 receptors, P2 receptors are also present in guinea-pig atria, mediating stimulatory effects of adenine compounds. Oral administration of synthetic oestrogen, ethinyl oestradiol in combination with progestogen, norgestrel for ten weeks significantly increased blood pressure and cardiac weight compared with those of the control rats.

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The randomized block method was used for statistical analyses of frequency and amount of daily watery fluid excretion and urine output, electrolyte levels in fluid secretions, as well as blood biochemistry, body weight and performance status. Simultaneous segmentation, kinetic parameter estimation, and uncertainty visualization of dynamic PET images.

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Complete resection is the most important prognostic factor in surgery for rectal cancer. Discovery Elbow System (DES) is a semi-constrained prosthesis, mainly used for patients with rheumatoid arthritis (RA). What can be expected from the cytologic examination of cervicovaginal smears for the diagnosis of Chlamydia trachomatis infections?